Human genetics, reproduction and prenatal development (BBS1005)

[titel(DNA and Gametogenesis)beschrijving(Explaining, discussing and practicing the following concepts: DNA; Mutations; DNA repair mechanisms; Gametogenesis; Epigenetics.)duur(90 minutes)]

[titel(Fertilisation)beschrijving(Explaining, discussing and practicing the following concepts: Anatomy of the female reproductive tract; Follicle formation; Fertilisation and development in week 1; Cleavage; Ovarian cycle; Pre-implantation genetic diagnosis.)duur(90 minutes)]

[titel(Regulation of Gene Expression)beschrijving(Explaining, discussing and practicing the following concepts: Transcription; RNA processing; Protein regulation; Motifs of regulatory proteins.)duur(90 minutes)]

[titel(Cell Cycle)beschrijving(Explaining, discussing and practicing the following concepts: Mitosis; Checkpoints; Mitogens; p53; CDKs; Regulation of the cell cycle.)duur(90 minutes)]

[titel(Implantation and Gastrulation)beschrijving(Explaining, discussing and practicing the following concepts: Development in week 2: zona pellucida, hatching, decidual reaction, Heuser’s membrane, secondary yolk sac, amniotic cavity, chorionic cavity, connecting stalk; Development in week 3: trilaminar disc, primitive streak, ecto/endo/mesoderm; Development in week 4: neural plate, notochord, neural crest, neural tube; primary and secondary neurulation; Gastrulation [development in week 2, 3, 4]: somites and body folds; Placenta: primary, secondary and tertiary stem villi; Twins.)duur(135 minutes)]

[titel(Monogenic Diseases)beschrijving(Explaining, discussing and practicing the following concepts: Pathogenic inheritance; LMNA and lamins; Cytogenetic methods; Molecular methods.)duur(70 minutes)]

[titel(Hox Genes and Segmentation Clock)beschrijving(Explaining, discussing and practicing the following concepts: Development in week 5; Hox genes; Vertebral column; Cranialisation, caudalisation; Somite differentiation; Somite formation and the segmentation clock [Wnt and FGF, Delta-Notch, Ephrin].)duur(90 minutes)]

[titel(Gut Development)beschrijving(Explaining, discussing and practicing the following concepts: Wnt; Fore/mid/hind gut; Gut organ development; Intra and primary and secondary retroperitoneal organs; Gut epithelium differentiation, proliferation and maintenance; Radial differentiation.)duur(90 minutes)]

[titel(Apoptosis and Limb Development)beschrijving(Explaining, discussing and practicing the following concepts: Apoptosis and necrosis; Caspase cascade; Limb development: proximal-distal, cranial-caudal, dorsal-ventral; Apoptosis in limb development.)duur(90 minutes)]

[titel(Sex Differentiation)beschrijving(Explaining, discussing and practicing the following concepts: Ambisexual stage; Male primary and secondary differentiation; Female primary and secondary differentiation; Sex reversal.)duur(135 minutes)]

[titel(Heart Development)beschrijving(Explaining, discussing and practicing the following concepts: Tube formation - week 3; Heart looping - week 4; Ballooning - week 5; Septation - week 6 and 7; Aorta; Valves - week 5-8; Conduction system; Epicardium and coronary vasculature; Before and after birth; Heart defects.)duur(90 minutes)]

[titel(miRNA)beschrijving(Explaining, discussing and practicing the following concepts: Function; Biogenesis; Gene regulation; RNAi interference; miRNA x siRNA; miRNA in embryonic development.)duur(70 minutes)]

[titel(Exam Simulation)beschrijving(90 minutes for exam-like questions; 60 minutes discussion of correct answers.)duur(150 minutes)]